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Ageing and Diseases


  1. Lauwers, M.; Au, M.; Yuan, S.; Wen, C. COVID-19 in Joint Ageing and Osteoarthritis: Current Status and Perspectives. Int. J. Mol. Sci. 2022, 23, 720.


  2. Liangbin Zhou, Jietao Xu, Andrea Schwab, Wenxue Tong, Jiankun Xu, Lizhen Zheng, Ye Li, Zhuo Li, Shunxiang Xu, Ziyi Chen, Li Zou, Xin Zhao, Gerjo J.V.M. van Osch, Chunyi Wen, Ling Qin, Engineered biochemical cues of regenerative biomaterials to enhance endogenous stem/progenitor cells (ESPCs)-mediated articular cartilage repair, Bioactive Materials, Volume 26, 2023, Pages 490-512, ISSN 2452-199X,

  3. Xiangbo Meng, Ling Li, Cuishan Huang, Keda Shi, Qingqiang Zeng, Chunyi Wen, Sibylle Grad, Mauro Alini, Ling Qin, Xinluan Wang, Anti-inflammatory and anabolic biphasic scaffold facilitates osteochondral tissue regeneration in osteoarthritic joints, Journal of Materials Science & Technology, Volume 156, 2023, Pages 20-31, ISSN 1005-0302,

  4. Chan LC, Zhang Y, Kuang X, Koohi-Moghadam M, Wu H, Lam TYC, Chiou J, Wen C. Captopril Alleviates Chondrocyte Senescence in DOCA-Salt Hypertensive Rats Associated with Gut Microbiome Alteration. Cells. 2022; 11(19):3173.

  5. Wu GF, Ma FB, Liu ZW, Liu JY, Xue YZB, Zhang MD, Wen CY, Tang B,  Lin LJ, Hybrid composites with magnesium-containing glycosaminoglycans as a chondroconducive matrix for osteoarthritic cartilage repair, International Journal of Biological Macromolecules, Volume 220, 2022, Pages 1104-1113, ISSN 0141-8130,

  6. Yujie Liang, Xiao Xu, Limei Xu, Zoya Iqbal, Kan Ouyang, Huawei Zhang, Chunyi Wen, Li Duan, Jiang Xia. Chondrocyte-specific genomic editing enabled by hybrid exosomes for osteoarthritis treatment. Theranostics 2022; 12(11): 4866-4878. doi: 10.7150/thno.69368

  7. Mark A Naven, Leo A.H. Zeef, Shiyang Li, Paul A Humphreys, Christopher A Smith, Dharshika Pathiranage, Stuart Cain, Steven Woods, Nicola Bates, Manting Au, Chunyi Wen, Susan J Kimber, and Qing-Jun Meng, Development of human cartilage circadian rhythm in a stem cell-chondrogenesis model, Theranostics, 2022; 12(8): 3963-3976. doi: 10.7150/thno.70893

  8. Ni, Guo, X. E., Yan, C., & Wen, C. (2022). Hemodynamic stress shapes subchondral bone in osteoarthritis: An emerging hypothesis. Journal of Orthopaedic Translation, 32, 85–90.

  9. Deng, Zhang, X., Li, R., Li, Z., Yang, B., Shi, P., Zhang, H., Wang, C., Wen, C., Li, G., & Bian, L. (2022). Biomaterial-mediated presentation of wnt5a mimetic ligands enhances chondrogenesis and metabolism of stem cells by activating non-canonical Wnt signaling. Biomaterials, 281, 121316–121316.

  10. Zou, Luo, X., Chen, Z., Zhang, Y. S., & Wen, C. (2022). Emerging microfluidics-enabled platforms for osteoarthritis management: From benchtop to bedside. Theranostics, 12(2), 891–909.

  11. Zhou, Ni, J., Wen, C., & Lai, P. (2022). Light on osteoarthritic joint: From bench to bed. Theranostics, 12(2), 542–557.

  12. Yin, Ni, J., Witherel, C. E., Yang, M., Burdick, J. A., Wen, C., & Dexter Wong, S. H. (2022). Harnessing tissue-derived extracellular vesicles for osteoarthritis theranostics. Theranostics, 27(1), 207–231.

  13. Shen, Hu, L., Li, Z., Wang, L., Pang, X., Wen, C.-Y., & Tang, B. (2021). Extracellular calcium ion concentration regulates chondrocyte elastic modulus and adhesion behavior. International Journal of Molecular Sciences, 22(18), 10034.

  14. Ni JG, Au MT, Kong HK, Wang XL, Wen CY. Lycium barbarum polysaccharides in ageing and its potential use for prevention and treatment of osteoarthritis: a systematic review. BMC Complement Med Ther 21, 212 (2021).

  15. Ching, Houard, X., Berenbaum, F., & Wen, C. (2021). Hypertension meets osteoarthritis — revisiting the vascular aetiology hypothesis. Nature Reviews. Rheumatology, 17(9), 533–549.

  16. Au, Shi, J., Fan, Y., Ni, J., Wen, C., & Yang, M. (2021). Nerve Growth Factor-Targeted Molecular Theranostics Based on Molybdenum Disulfide Nanosheet-Coated Gold Nanorods (MoS2‑AuNR) for Osteoarthritis Pain. ACS Nano, 15(7), 11711–11723.

  17. Zhang, & Wen, C. (2021). Osteocyte dysfunction in joint homeostasis and osteoarthritis. International Journal of Molecular Sciences, 22(12), 6522.

  18. Lo, Au, M., Ni, J., & Wen, C. (2022). Association between hypertension and osteoarthritis: A systematic review and meta-analysis of observational studies. Journal of Orthopaedic Translation, 32, 12–20.

  19. Kuang XQ, Chiou JC, Lo K, Wen CY. Magnesium in joint health and osteoarthritis. Nutrition Research, 2021 Jun, 90, 24-35.

  20. Lauwers M, Courties A, Sellam J, Wen C. The cholinergic system in joint health and osteoarthritis: a narrative-review Osteoarthritis Cartilage. 2021 Feb 17:S1063-4584(21)00041-8.

  21. Meng, Grad, S., Wen, C., Lai, Y., Alini, M., Qin, L., & Wang, X. (2021). An impaired healing model of osteochondral defect in papain-induced arthritis. Journal of Orthopaedic Translation, 26, 101–110.

  22. Au, Liu, Z., Rong, L., Zheng, Y., & Wen, C. (2020). Endothelin-1 induces chondrocyte senescence and cartilage damage via endothelin receptor type B in a post-traumatic osteoarthritis mouse model. Osteoarthritis and Cartilage, 28(12), 1559–1571.

  23. Huang Y, Chan CH, Zhou H, Zheng Y, Yan CH, Wen C. 3D High-Frequency Ultrasound Imaging of Cartilage-Bone Interface Compared with Micro-CT. BioMed Research International 2020 Jun;2020:6906148. doi: 10.1155/2020/6906148.

  24. Lim, Wen, C., & Vincent, T. . (2020). Molecular and structural imaging in surgically induced murine osteoarthritis. Osteoarthritis and Cartilage, 28(7), 874–884.

  25. Meng X, Ziadlou R, Grad S, Alini M, Wen C, Lai Y, Qin L, Zhao Y, Wang X. Animal Models of Osteochondral Defect for Testing Biomaterials. Biochem Res Int. 2020 Jan 28;2020:9659412. doi: 10.1155/2020/9659412.

  26. Lin, L J, Ge, Y M, Tian, Y, Liu, N, Luo, X H, Xue, Y T, Xue, Y Z B, Wen, C Y, and Tang, B. "Multi-scale Mechanical Investigation of Articular Cartilage Suffered Progressive Pseudorheumatoid Dysplasia." Clinical Biomechanics (Bristol, Avon) 2020 Oct;79:104947. doi: 10.1016/j.clinbiomech.2019.12.029.

  27. Wen. (2019). High Blood Pressure and Osteoarthritis: Friends or Foes? Comment on the Article by Funck‐Brentano et al. Arthritis & Rheumatology (Hoboken, N.J.), 71(12), 2131–2132.

  28. Weber A, Chan PMB, Wen C. Do immune cells lead the way in subchondral bone disturbance in osteoarthritis? Prog Biophys Mol Biol. 2019 Nov; 148:21-31.

  29. Liu Z, Au M, Wang X, Chan PB, Lai P, Sun L, Zheng Y, Rong L, Wen C. Photoacoustic imaging of synovial tissue hypoxia in experimental post-traumatic osteoarthritis. Prog Biophys Mol Biol. 2019 Nov; 148:12-20.

  30. Weber A, Mak SH, Berenbaum F, Sellam J, Zheng YP, Han Y, Wen C. Association between osteoarthritis and increased risk of dementia: A systemic review and meta-analysis. Medicine (Baltimore). 2019 Mar;98(10): e14355. doi: 10.1097/MD.0000000000014355.

  31. Zhang C, Chiu KY, Chan BPM, Li T, Wen C, Xu A, Yan CH. Knocking out or pharmaceutical inhibition of fatty acid binding protein 4 (FABP4) alleviates osteoarthritis induced by high-fat diet in mice. Osteoarthritis Cartilage. 2018 Jun;26(6):824-833.

  32. Zhang C, Li T, Chiu KY, Wen CY, Xu A, Yan CH. FABP4 as a biomarker for knee osteoarthritis. Biomark Med. 2018 Feb_12(2)107-118. doi 10.2217bmm-2017-0207.

  33. Chan PMB, Wen C, Yang WC, Yan C, Chiu K. Is subchondral bone cyst formation in non-load-bearing region of osteoarthritic knee a vascular problem? Med Hypotheses. 2017 Nov;109:80-83.

  34. Chan B, Wen CY#. Spontaneous hypertensive rat exhibits bone and meniscus phenotypes of osteoarthritis: is it an appropriate control for MetS-associated OA? Annals of the Rheumatic Diseases 2018 May;77(5):e25. doi: 10.1136/annrheumdis-2017-211995.

  35. Huang YP, Zhong J, Chen J, Yan CH, Zheng YP, Wen CY#. High frequency ultrasound imaging of tidemark in vitro in advanced knee osteoarthritis. Ultrasound in Medicine and Biology 2018 Jan;44(1):94-101

  36. Ma, F, Liu N, Hu N, Wen CY, Tang B. "Synthesis of strontium chondroitin sulfate and the evaluation of its capability to attenuate osteoarthritis". Carbohydrate Polymers, 2017(170): 217-225.

  37. Zhao W, Wang T, Luo Q, Chen Y, Leung VY, Wen C, Shah MF, Pan H, Chiu K, Cao X, Lu WW. Cartilage degeneration and excessive subchondral bone formation in spontaneous osteoarthritis involves altered TGF-β signaling. J Orthop Res. 2016 May;34(5):763-70.

  38. Chan P, Zhu L, Wen CY, Chiu KY. Subchondral bone proteomics in osteoarthritis: Current status and perspectives. Journal of Orthopaedic Translation 2015: 3 (2), 71-77

  39. Sin A, Tang W, Wen C, Chung SK, Chiu KY. The emerging role of endothelin-1 in the pathogenesis of subchondral bone disturbance and osteoarthritis. Osteoarthritis & Cartilage 2015 Apr;23(4):516-24.

  40. Wen, C. & Lohmander, L. S. Does post-injury ACL reconstruction prevent future OA? Nat. Rev. Rheumatol. 2014 Oct;10(10):577-8.

  41. Tang B, Fong MK, Wen CY, Yan CH, Chan D, Ngan A, Chiu KY, Lu WW. Nanostiffness of Collagen Fibrils Extracted From Osteoarthritic Cartilage Characterized with AFM Nanoindentation. Soft Materials 2014 12(3) 253-261.

  42. Wen CY, Lu W, Chiu KY. Importance of subchondral bone in pathogenesis and management of osteoarthritis - from bed to bench. Journal of Orthopaedic Translation 2014 Jan 2(1) 16-25.

  43. Wen C, Chen Y, Tang HL, Yan CH, Lu WW, Chiu KY. Bone loss at subchondral plate in knee osteoarthritis patients with hypertension and type 2 diabetes mellitus. Osteoarthritis & Cartilage. 2013 Nov; 21(11): 1716-23.

  44. Zhen GH, Wen CY, Jia XF, Li Y, Mears S, Askin F, Frassica F, Chang W, Crane J, Yao J, Nayfeh T, Johnson C, Artemov D, Cosgarea A, Carrino J, Wan M, Lu W and Cao X. Inhibition of TGFβ signaling in subchondral bone mesenchymal stem cells prevents onset of osteoarthritis. Nature Medicine 2013 Jun; 19(6): 704-12.

  45. Wang T, Wen CY, Yan CH, Lu WW, Chiu KY. Spatial and Temporal Changes of Subchondral Bone Proceeds to Articular Cartilage Degeneration in Guinea Pigs with Spontaneous Osteoarthritis. Osteoarthritis & Cartilage 2013 Apr; 21(4): 574-81.Wen CY, Wu CB, Tang.

  46. Wen CY, Wu CB, Tang B, Wang T, Yan CH, Lu WW, Pan H, Hu Y, Chiu KY. Collagen Fibril Stiffening in Osteoarthritic Cartilage of Human Beings Revealed by Atomic Force Microscopy. Osteoarthritis & Cartilage. 2012 Aug; 20(8): 916-22.


  47. Yuhe Yang, Jingdong Rao, Huaqian Liu, Zhifei Dong, Zhen Zhang, Ho-Pan Bei, Chunyi Wen, Xin Zhao, Biomimicking design of artificial periosteum for promoting bone healing, Journal of Orthopaedic Translation, Volume 36, 2022, Pages 18-32, ISSN 2214-031X.

  48. Luo XH, Lauwers M, Layer PG, Wen CY. Non-Neuronal Role of Acetylcholinesterase in Bone Development and Degenerations Int. 2020 Dec 28. doi: 10.3389/fcell.2020.620543 

  49. Liu ZY, Au MT, He TW, Yang B, Liu B, Zhang LM, Luo CX, Rong LM, Wen CY. Less Vertebral Bone Mass after Treatment with Macitentan in Mice: A Pilot Study. Biomed Res Int. 2019 Feb 19;2019:2075968. doi: 10.1155/2019/2075968.

  50. Liu ZY, Yang, Y, Wen CY, Rong LM "Serum Osteocalcin and Testosterone Concentrations in Adult Males with or without Primary Osteoporosis: A Meta-Analysis". Biomed Res Int. 2017; 2017:9892048. doi: 10.1155/2017/9892048.

  51. Qiu T, Xian L, Crane J, Wen C, Hilton M, Newman P, Lu W, Cao X. PTH receptor signaling in osteoblasts regulates endochondral vascularization in maintenance of postnatal growth plate. J Bone Miner Res. 2015 Feb; 30 (2):309-17.

  52. Xian LL, Lou M, Wu XW, Yu B, Frank Frassica F, Wan M, Pang LJ, Wen CY, Tryggestad E, Wong J, Xu Cao X. Pretreatment with antioxidants prevent bone injury by improving bone marrow microenvironment for stem cells. Stem Cell Discovery 2012 July 2(3): 100-107.

  53. Shen YH, Liu WC, Wen CY, Pan HB, Wang T, Darvell BW, Lu WW, Huang WH. Local pH in Bone Regeneration: Strontium-doped Borosilicate Scaffold. Journal of Materials Chemistry 2012 (22) 8662-8670.

  54. Shen Y, Liu W, Lin K, Pan H, Darvell BW, Peng S, Wen C, Deng L, Lu WW, Chang J. Interfacial pH – a critical factor for osteoporotic bone regeneration. Langmuir, 2011, 27 (6), pp 2701–2708.

  55. Cao X, Wu X, Frassica D, Yu B, Pang L, Xian L, Wan M, Lei W, Armour M, Tryggestad E, Wong J, Wen CY, Lu WW, Frassica FJ. Irradiation induces bone injury by damaging bone marrow microenvironment for stem cells. Proc Natl Acad Sci U S A. 2011 Jan 25; 108(4): 1609-14.

    Tendon & Ligament Injury

  56. Yao J, Wen CY, Zhang M, Cheung JT, Yan C, Chiu KY, Lu WW, Fan Y. Effect of tibial drill-guide angle on the mechanical environment at bone tunnel aperture after anatomic single-bundle anterior cruciate ligament reconstruction. International Orthopaedics. 2014 May; 38(5): 973-81.

  57. Yao J, Wen CY, Cheung JT, Zhang M, Yan CH, Chiu KY, Hu Y, Lu WW, Fan YB. The deterioration of stress distribution due to tunnel creation in single-bundle and double-bundle anterior cruciate ligament reconstructions – A finite element analysis. Annals of Biomedical Engineering 2012 Jul; 40(7): 1554-67.

  58. Peng J, Wen C*, Wang A, Wang Y, Xu W, Zhao B, Zhang L, Lu S, Qin L, Guo Q, Dong L, Tian J. Micro-CT based Bone Ceramic Scaffolding and its Performance when Seeded by Marrow-Derived Mesenchymal Stem Cells for Reconstruction of Load-bearing Bone of Femoral Head in A Canine Model. J Biomed Mater Res B Appl Biomater. 2011 Feb; 96(2): 316-25.

  59. Qin L, Wang L, Wong MW, Wen C, Wang G, Zhang G, Chan KM, Cheung WH, Leung KS. Osteogenesis induced by extracorporeal shockwave in treatment of delayed osteotendinous junction healing. J Orthop Res. 2010 Jan; 28(1): 70-6.

  60. Wen CY, Qin L, Lee KM, Wong MW, Chan KM. Grafted tendon healing in tibial tunnel is inferior to healing in femoral tunnel after anterior cruciate ligament Reconstruction: a histomorphometric study in rabbits. Arthroscopy. 2010 Jan; 26(1): 58-66.

  61. Wen CY, Qin L, Lee KM, Wong MW, Chan KM. Influence of bone adaptation on tendon-to-bone healing in bone tunnel after anterior cruciate ligament Reconstruction in a rabbit model. J Orthop Res. 2009 Nov; 27(11): 1447-56.

  62. Wen CY, Qin L, Lee KM, Chan KM. The use of brushite calcium phosphate cement for enhancement of bone-tendon integration in an anterior cruciate ligament reconstruction rabbit model. J Biomed Mater Res B Appl Biomater. 2009 May; 89B(2): 466-74.

  63. Wen CY, Qin L, Lee KM, Chan KM. Peri-graft bone mass and connectivity as Predictors for the strength of tendon-to-bone attachment after anterior cruciate Ligament reconstruction. Bone. 2009 Sep; 45(3): 545-52. Spinal Cord injury

    Spinal Cord injury

  64. Wen CY, Liu HS, Cui JL, Mak KC, Cheung WY, Hu Y, Luk DK. Is Diffusion Anisotropy A Biomarker for Disease Severity and Surgical Prognosis of Cervical Spondylotic Myelopathy? Radiology 2014 Jan; 270(1):197-204.

  65. Wen CY, Cui JL, Mak KC, Luk DK, Hu Y. Diffusion Tensor Imaging of Somatosensory Tract in Cervical Spondylotic Myelopathy and Its Link with Electrophysiological Evaluation. Spine J 2014 Aug 1;14(8):1493-500.

  66. Wen CY, Lee MP, Cui JL, Mak KC, Luk DK, Hu Y. Fiber Tractography as A Diagnostic Tool for Cervical Spondylotic Myelopathy. Spine J 2013 Jun; 13(6): 697-705.

  67. Long HQ, Li GS, Hu Y, Wen CY, Xie WH. HIF-1α/VEGF signaling pathway may play a dual role in secondary pathogenesis of cervical myelopathy. Med Hypotheses. 2012 Jul; 79(1): 82-4.

  68. Cui JL, Wen CY, Hu Y, Mak KC, Mak KH, Luk KD. Orientation entropy analysis of diffusion tensor in healthy and myelopathic spinal cord. Neuroimage. 2011 Oct 15; 58(4): 1028-33.

  69. Hu Y, Wen CY, Li TH, Cheung MM, Wu EX, Luk KD. Somatosensory-Evoked Potentials as an Indicator for the Extent of Ultrastructural Damage of Spinal Cord after Chronic Compressive Injuries in a Rat Model. Clin Neurophysio. 2011 Jul; 122(7): 1440-7.

  70. Cui JL, Wen CY, Hu Y, Li TH, Luk KD. Entropy-based Analysis for Diffusion Anisotropy Mapping of Healthy and Myelopathic Spinal Cord. Neuroimage. 2011 Feb 1; 54(3): 2125-31.


  71. Ying-kun Cui, Li Pan, Tim Lam, Chun-yi Wen & Chi-wai Do (2021) Mechanistic links between systemic hypertension and open angle glaucoma, Clinical and Experimental Optometry, DOI: 10.1080/08164622.2021.1964332

  72. Suk-yu Yau, Yvette Siu Ling Yip, Douglas A. Formolo, Siyuen He, Thomas Ho Yin Lee, Chunyi Wen, Deanne H. Hryciw, Chronic consumption of a high linoleic acid diet during pregnancy, lactation and post-weaning period increases depression-like behavior in male, but not female offspring, Behavioural Brain Research, Volume 416, 2022, 113538, ISSN 0166-4328,

    Ageing Data Registry

  73. Hin Ting Victor Yick, Ping Keung Chan, Chunyi Wen, Wing Chiu Fung, Chun Hoi Yan, & Kwong Yuen Chiu. (2022). Artificial intelligence reshapes current understanding and management of osteoarthritis: A narrative review. Journal of Orthopaedics, Trauma and Rehabilitation, 29.

  74. Lee, Chan, P. K., Wen, C., Fung, W. C., Cheung, A., Chan, V. W. K., Cheung, M. H., Fu, H., Yan, C. H., & Chiu, K. Y. (2022). Artificial intelligence in diagnosis of knee osteoarthritis and prediction of arthroplasty outcomes: a review. Arthroplasty, 4(1), 16–16.

  75. Cheung,J.C.-W.;Tam, A.Y.-C.; Chan, L.-C.; Chan, P.-K.; Wen, C. Superiority of Multiple-Joint Space Width over Minimum-Joint Space Width Approach in the Machine Learning for Radiographic Severity and Knee Osteoarthritis Progression. Biology2021,10,1107. https://

  76. Chan L, Li H, Chan PK, Wen CY. A machine learning-based approach to decipher multi-etiology of knee osteoarthritis onset and deterioration. Osteoarthritis Cartilage Open, 2021, 3(1): 100135.



  77. Chen Z, Jiang K, Zou Z, Luo X, Lim CT Wen CY. “High-Throughput and Label-Free Isolation of Senescent Murine Mesenchymal Stem Cells.” Biomicrofluidics, 2020 May 21;14(3):034106.

  78. Cheng C, Zhang R, Wang J, Zhang Y, Wen C, Tan Y, Yang M. An ultrasensitive and selective fluorescent nanosensor based on porphyrinic metal-organic framework nanoparticles for Cu2+ detection. Analyst. 2020 Feb 3;145(3):797-804.

  79. Chen ZK, Luo XH, Zhao X, Yang M, Wen CY. Label-free cell sorting strategies via biophysical and biochemical gradients. Journal of Orthopaedic Translation. 2019 Feb 26;17:55-63.

  80. Oudeng G, Au MT, Shi JY, Wen CY, Yang M. One-Step in Situ Detection of miRNA-21 Expression in Single Cancer Cells Based on Biofunctionalized MoS Nanosheets. ACS Applied Materials Interfaces 2018 10 (1), 350-360.

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