Only the best is good enough.

Skeletal Ageing Research and Therapy (ART) Laboratory

It is to advance the understanding, early detection, treatment and prevention of osteoarthritis through data-driven innovations.

Definition of OA

Osteoarthritis is a disorder involving movable joints characterized by cell stress and extracellular matrix degradation initiated by micro- and macro-injury that activates maladaptive repair responses including pro-inflammatory pathways of innate immunity. The disease manifests first as a molecular derangement (abnormal joint tissue metabolism) followed by anatomic, and/or physiologic derangements (characterized by cartilage degradation, bone remodeling, osteophyte formation, joint inflammation and loss of normal joint function), that can culminate in illness.

Source: The Osteoarthritis Action Alliance (OAAA)

Latest News

Oct 22, 2019 

BME Research Seminar

Inflammation and Osteoarthritis

Research Highlights


Cellular Senescence and Skeletal Aging:

Molecular Mechanism, Drug discovery and Clinical Implications


Precision Medicine for

Skeletal Ageing:

Deep-learning Patient-specific Prediction Model for Knee Osteoarthritis


Data-driven Community-based Bone & Joint Healthcare Revolution





Endothelins are vasoconstricting peptides, which play an essential role in vascular homeostasis (e.g. blood pressure). Hypertension is believed that it has high correlation with Osteoarthritis. This Project studies the effects of Endothelins on articular cartilage from its structures to its applications. 

Funded by PROCORE-France/Hong Kong Joint Research Scheme, Research Grants Council  

Endothelins in Health and Disease of Articular Cartilage - From Mechanism Towards Theraputics 

MB.BS, M.Med.Sc., Ph.D.

Principal Investigator,
Assistant Professor

Dr. Chunyi Wen

Our Team


*Below equipments are used for different purposes upon the levels of investigation from tissue, cellular, animal and human samples.* (please provide me the text)


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